theCatch

Ozempic muscle loss — fat or muscle?

Ozempic and Wegovy melt away the pounds — but what kind of weight are you losing? A 2024 review of six randomized trials tested the claim.

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88-ozempic-muscle-loss.mdSOURCES CHECKED
Claim
OZEMPIC MUSCLE LOSS?
Catch
MUSCLE LOSS
Verdict
PROTECT YOUR MUSCLE

The study: six RCTs, 1,541 overweight or obese adults taking semaglutide. Researchers tracked whether the weight lost was fat or lean body mass (mostly muscle).

Most of the weight lost was fat mass — that's the goal. But a meaningful share was lean body mass. Lean mass reduction ranged from zero to forty percent of the total weight lost, depending on the trial.

Muscle matters — it burns calories and keeps you strong. The catch: six trials of varying size and duration, and the proportion of muscle loss differed between studies. Pair semaglutide with strength training and enough protein to protect lean mass.

SOURCES

  1. Expert Opin Pharmacother. 2024
  2. doi:10.1080/14656566.2024.2343092.

For information only, not medical advice. Talk to your doctor before starting any medication.

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